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 In the US Nerve-Express products are for INVESTIGATIONAL USE ONLY.

            For FDA 510K cleared device see  www.intellewave.net


Nerve-Express is a fully automatic, non-invasive computer-based system designed for quantitative assessment of the Autonomic Nervous System (ANS) based on Heart Rate Variability (HRV) analysis. 
Nerve-Express is the first and only system to solve the problem of SNS-PSNS quantification based on method of

Clusterization of the relationship between SNS and PSNS status

This technological breakthrough is achieved by using proprietary algorithms and a new approach based on one of the leading theories of Artificial Intelligence - Marvin Minsky's Frame Theory. Nerve-Express objectively and reliably evaluates the state of ANS in "real-time" (up to 24 hours) as well as during Orthostatic test and Valsalva maneuver combined with Deep Breathing. Due to its highly sophisticated HRV analysis, Nerve-Express is the only system that enables quantification of 81 ANS states with a corresponding qualitative description for each one.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          

Valsalva Maneuver combined with Deep breathing                                           

 The algorithms used by Nerve-Express have been developed and tested for over twenty five years in studies involving more than  twenty thousand patients . Nerve-Express implements a battery of three tests as the most  comprehensive and informative combination of tests for ANS  purposes:

1. Orthostatic test as the initial method for ANS provocation;

2. Valsalva maneuver combined with Deep Breathing as the optimal method for revealing the hidden abilities of the Autonomic function and distinguishing between chronic and temporary abnormalities;

3. Real-time Nerve-Monitor test as the ultimate method for ANS assessment in long-term therapy, continuous monitoring (especially, under anesthesia/intensive care), research and experimentation. Real-Time assessment may be conducted on a single patient as well as on two patients simultaneously for psychological purposes for instance: as a lay detector or psychological adaptation between crew members.              

                Orthostatic intervention (lying -to-standing test)



      Common Interpretation of 2 tests result 



"Real- Time" Autonomic  Monitor                                                                                                                       656

3D Spectral function of  "Real- Time" Autonomic  Monitor



  24 hour of Autonomic function on one screen to see the difference between "Sleep" and "Awake" time